ÓÄÃÅÂÝÐý¸Ë¾ú£¬Ò»Ïî³£¼ûµÄ¿í·ºÐÔ´«²¼¼²²¡¡£Ëüͨ³£»á¼ÄÉúÔÚθճĤ×éÖ¯ÖУ¬Ï°È¾ºóÖØÒªÒýÆðÂýÐÔθÑ׺ÍÏû»¯ÐÔÀ£ÑñµÈ¼²²¡£¬Óëθ°©¡¢Î¸Õ³Ä¤ÓйØÁܰÍ×éÖ¯ÁܰÍÁöµÈ¼²²¡ÓÐÇ×êǹØÏµ£¬±»ÊÀ½çÎÀÉú×éÖ¯ÁÐΪµÚÒ»ÀàÉúÎïÖ°©Òò×Ó¡£
ÔÚÎÒ¹úÓÄÃÅÂÝÐý¸Ë¾ú¾ùÔÈϰȾÂÊΪ50%£¬Î÷±±¡¢Î÷ÄϺͶ«²¿µØÓòϰȾÂÊÏà¶Ô½Ï¸ß£¬ÆäÖÐÎ÷²Ø¡¢¹óÖÝ¡¢¸ÊËà±ðÀëÒÔ66%¡¢61%¡¢57%µÄϰȾÂÊλ¾ÓǰÈýλ¡£Ï°È¾ÂÊ×îµÍµÄÈý¸öµØÓò±ðÀëÊÇÌì½ò¡¢ÇຣºÍ³ÁÇ죬±ðÀëΪ36%¡¢36%¡¢35%¡£
˼¿¼µ½ÎÒ¹úÖ÷Á÷Óòͷ½Ê½ÒÔ¼°ÓÄÃÅÂÝÐý¸Ë¾úµÄÖØÒª´«²¼·½Ê½£¬Ê¹Óøɾ»µÄ²Í¾ßºÍ·Ö²ÍÔìÒ»ÏòÊÇÔ¤·ÀµÄ³ÁÖÐÖ®³Á£¬µ«ÊÇϰȾºóΪÁËÉí±ßÇ×ÓѵĽ¡È«£¬»¹ÊÇÓ¦¼°Ôç¹ýÎÊ¡£
Ò»¡¢ÓÄÃÅÂÝÐý¸Ë¾úÔõôҽÖÎ
1¡¢ÈýÁªÁÆ·¨£ºÓÉÖÊ×Ó±ÃÒÖÔì¼Á£¨PPI£©»òîé¼Á½áºÏÁ½ÖÖ¿¹ÉúËØ×é³É£¬¾ßÌåΪPPI+¿ËÀÃ¹ËØ+°¢ÄªÎ÷ÁÖ»òPPI+¼×Ïõßò¡£µ«ÊǽüÄêÀ´£¬ÎÒ¹úÓÄÃÅÂÝÐý¸Ë¾ú¶Ô¿ËÀÃ¹ËØ¡¢¼×ÏõßòºÍ×óÑõ·úɳÐÇ£¨·úàŵͪÀࣩÄÍÒ©ÂÊÉÏÉý£¬Òò¶ø£¬ÈýÁª·¨Ò²Öð²½±»°Î³ý¡£
2¡¢ËÄÁªÁÆ·¨£ºÄ¿Ç°ÍƼö¡¹úé¼ÁËÄÁª¡±×÷ÎªÖØÒªµÄ¾ÑéÐÔ¸ù³ýÓÄÃÅÂÝÐý¸Ë¾ú¹æ»®£¬Ô̺¬îé¼Á+PPI+Á½ÖÖ¿¹ÉúËØ¡£¾µäîé¼ÁËÄÁª¹æ»®ÓÉPPI+îé¼Á+ËÄ»·ËØ+¼×Ïõßò×é³É
¶þ¡¢Ò½ÖÎÓÄÃÅÂÝÐý¸Ë¾úîé¼ÁµÄ×÷ÓÃ
ÔÚËÄÁªÁÆ·¨ÖУ¬î黯ºÏÎïÔì×÷µÏëé¼ÁÆðµ½Á˼«¶È³ÁÒªµÄ×÷Óá£Ëü»áÆðµ½·ÖÆçˮƽµØ±£»¤Î¸ð¤Ä¤£¬ÍƽøÀ£ÑñճĤÔÙÉúºÍÓúºÏµÄ×÷Óᣵ«ÊÇ£¬ÓÐЩîé¼Á¿ÉÄÜ»áÓÐһЩ²»Á¼·´Ó³£¬ºÃ±È·þÓúóθÕÍÆøµÈ¸±×÷Ó㬲¢ÇÒîé¼Á×÷Ϊ½ðÊôÔªËØÔì¼Á£¬½øÈëÈËÌå´úлʼÖÕÊǸ÷ÈËËù²»°²µÄ¡£
Å·²©ABGÔìÒ©³ö²úµÄ°²ÌØ?½ºÌå¹û½ºîé°²ÉíÁÙ´²£¬Í¨¹ý´óÁ¿ÁÙ´²³ÉЧ¶Ô±È£¬È·¶¨°²È«ÐÔ¡¢ÓÐЧÐÔ¡£
1¡¢½ºÌå¹û½ºîéÒ©´ú¶¯Á¦Ñ§¼°°²È«ÐÔ×êÑÐ
Á˾֣ºîéÎüÊÕÁ¿( ÒÔ AUC0£tºÍCmax¼Æ) ½ºÌå¹û½ºî齺ÄÒ£¼½ºÌå¹û½ºîé¿ÅÁ££¼èÛéÚËáî鼨¿ÅÁ££¼èÛéÚËáîé¼ØÆ¬£¬Åú×¢ÊÜÊÔÔì¼ÁµÄÈËÌåîéÎüÊÕµÍÓڲαÈÔì¼Á¡£
½áÂÛ£º½¡È«ÊÜÊÔÕßµ¥´Î¿Ú·þ½ºÌå¹û½ºîé¿ÅÁ£¡¢½ºÌå¹û½ºî齺ÄÒµÄÈËÌåîéÎüÊÕµÍÓÚèÛéÚËáîé¼ØÆ¬ºÍèÛéÚËáî鼨¿ÅÁ££¬ÓµÓÐÓÅÁ¼µÄ°²È«ÐÔ¡£

2¡¢½ºÌå¹û½ºîéÈËÌåÎüÊÕ×êÑÐ
Á˾֣ºîéµÄÎüÊÕÁ¿ÓɶൽÉÙ˳´ÎΪ£º½ºÌå´ÎèÛéÚËáî鯬 > èÛéÚËáî鼨½ºÄÒ >½ºÌ¬¹û½ºî齺ÄÒ
ÎüÊÕ¿ì¶Å×ɿ쵽Âý˳´ÎΪ£º½ºÌå´ÎèÛéÚËáî鯬 > èÛéÚËáî鼨½ºÄÒ > ½ºÌ¬¹û½ºî齺ÄÒ
½áÂÛ£ºÏà±Å×ÚèÛéÚËáî鼨½ºÄҺͽºÌå´ÎèÛéÚËáî鯬£¬»¼ÕßÔÚ¿Ú·þ½ºÌ¬¹û½ºî齺ÄÒºóîéµÄÎüÊÕÔ½·¢»ºÂý£¬ÇÒÎüÊÕÁ¿¼«ÉÙ£¬°²È«¿¿µÃס¡£

3¡¢¹û½ºîéËÄÁªÁÆ·¨Ò½Öγà×ÓHpÓйØÎ¸Ñ×ÁÆÐ§×êÑÐ
Á˾֣ºÒ½ÖÎ×éÒ½ÖÎ×ÜÓÐЧÂÊ¡¢ÓÄÃÅÂݸ˾ú½â³ýÂʾù¸ßÓÚ¶ÔÕÕ×é( P £¼ 0. 05) ; Ò½ÖÎ×é²»Á¼·´Ó³²úÉúÂʵÍÓÚ¶ÔÕÕ×é( P £¼ 0. 05) ¡£
½áÂÛ£ºÔÚ³à×ÓÓÄÃÅÂݸ˾úÓйØÐÔθÑ×µÄÁÙ´²Ò½ÖÎÖУ¬ÀûÓú¬îé¼ÁËÄÁªÁÆ·¨Ò½ÖÎÁÆÐ§È·ÇÓ×¢ÎÞÑϳÁ²»Á¼·´Ó³¡£

Èý¡¢Å·²©ABGÔìÒ©°²ÐÀ?½ºÌå¹û½ºîé²úÆ·ÓÅÊÆ¡ª¡ªµÚÈý´úîéÔì¼Á£¬°²È«ÓÐЧ»¤Î¸¼Á
1¡¢´ÓÒ©ÎïÆô³Ì£ºÊÀ½ç³õ´´ÔÑÐÒ©Æ·£»Ò©Æ·³ß¶È¸ßÓÚ¹ú¶È³ß¶È¡£
2¡¢´Ó»¼Õ߯ô³Ì£º¼ÛÖµÊÊÖУ¬Ò×ÓÚ½ÓÊÜ£»¹æ¸ñ¶à¶à£¬ÁÙ´²Ñ¡Ôñ¶àÑù»¯¡£
3¡¢´ÓÉç»áÆô³Ì£ºÈÙ»ñ2012Äê¡°Äê¶È²ÔÉú°²ÐĽ±¡±µÈ¶àÏîÈÙÓþ£»È«¹ú³©Ïú30Ä꣬°²È«ÓÐЧ»ñÈϿɡ£

ÓÄÃÅÂÝÐý¸Ë¾ú£¬Ò»Ïî³£¼ûµÄ¿í·ºÐÔ´«²¼¼²²¡¡£Ëüͨ³£»á¼ÄÉúÔÚθճĤ×éÖ¯ÖУ¬Ï°È¾ºóÖØÒªÒýÆðÂýÐÔθÑ׺ÍÏû»¯ÐÔÀ£ÑñµÈ¼²²¡£¬Óëθ°©¡¢Î¸Õ³Ä¤ÓйØÁܰÍ×éÖ¯ÁܰÍÁöµÈ¼²²¡ÓÐÇ×êǹØÏµ£¬±»ÊÀ½çÎÀÉú×éÖ¯ÁÐΪµÚÒ»ÀàÉúÎïÖ°©Òò×Ó¡£
ÔÚÎÒ¹úÓÄÃÅÂÝÐý¸Ë¾ú¾ùÔÈϰȾÂÊΪ50%£¬Î÷±±¡¢Î÷ÄϺͶ«²¿µØÓòϰȾÂÊÏà¶Ô½Ï¸ß£¬ÆäÖÐÎ÷²Ø¡¢¹óÖÝ¡¢¸ÊËà±ðÀëÒÔ66%¡¢61%¡¢57%µÄϰȾÂÊλ¾ÓǰÈýλ¡£Ï°È¾ÂÊ×îµÍµÄÈý¸öµØÓò±ðÀëÊÇÌì½ò¡¢ÇຣºÍ³ÁÇ죬±ðÀëΪ36%¡¢36%¡¢35%¡£
˼¿¼µ½ÎÒ¹úÖ÷Á÷Óòͷ½Ê½ÒÔ¼°ÓÄÃÅÂÝÐý¸Ë¾úµÄÖØÒª´«²¼·½Ê½£¬Ê¹Óøɾ»µÄ²Í¾ßºÍ·Ö²ÍÔìÒ»ÏòÊÇÔ¤·ÀµÄ³ÁÖÐÖ®³Á£¬µ«ÊÇϰȾºóΪÁËÉí±ßÇ×ÓѵĽ¡È«£¬»¹ÊÇÓ¦¼°Ôç¹ýÎÊ¡£
Ò»¡¢ÓÄÃÅÂÝÐý¸Ë¾úÔõôҽÖÎ
1¡¢ÈýÁªÁÆ·¨£ºÓÉÖÊ×Ó±ÃÒÖÔì¼Á£¨PPI£©»òîé¼Á½áºÏÁ½ÖÖ¿¹ÉúËØ×é³É£¬¾ßÌåΪPPI+¿ËÀÃ¹ËØ+°¢ÄªÎ÷ÁÖ»òPPI+¼×Ïõßò¡£µ«ÊǽüÄêÀ´£¬ÎÒ¹úÓÄÃÅÂÝÐý¸Ë¾ú¶Ô¿ËÀÃ¹ËØ¡¢¼×ÏõßòºÍ×óÑõ·úɳÐÇ£¨·úàŵͪÀࣩÄÍÒ©ÂÊÉÏÉý£¬Òò¶ø£¬ÈýÁª·¨Ò²Öð²½±»°Î³ý¡£
2¡¢ËÄÁªÁÆ·¨£ºÄ¿Ç°ÍƼö¡¹úé¼ÁËÄÁª¡±×÷ÎªÖØÒªµÄ¾ÑéÐÔ¸ù³ýÓÄÃÅÂÝÐý¸Ë¾ú¹æ»®£¬Ô̺¬îé¼Á+PPI+Á½ÖÖ¿¹ÉúËØ¡£¾µäîé¼ÁËÄÁª¹æ»®ÓÉPPI+îé¼Á+ËÄ»·ËØ+¼×Ïõßò×é³É
¶þ¡¢Ò½ÖÎÓÄÃÅÂÝÐý¸Ë¾úîé¼ÁµÄ×÷ÓÃ
ÔÚËÄÁªÁÆ·¨ÖУ¬î黯ºÏÎïÔì×÷µÏëé¼ÁÆðµ½Á˼«¶È³ÁÒªµÄ×÷Óá£Ëü»áÆðµ½·ÖÆçˮƽµØ±£»¤Î¸ð¤Ä¤£¬ÍƽøÀ£ÑñճĤÔÙÉúºÍÓúºÏµÄ×÷Óᣵ«ÊÇ£¬ÓÐЩîé¼Á¿ÉÄÜ»áÓÐһЩ²»Á¼·´Ó³£¬ºÃ±È·þÓúóθÕÍÆøµÈ¸±×÷Ó㬲¢ÇÒîé¼Á×÷Ϊ½ðÊôÔªËØÔì¼Á£¬½øÈëÈËÌå´úлʼÖÕÊǸ÷ÈËËù²»°²µÄ¡£
Å·²©ABGÔìÒ©³ö²úµÄ°²ÌØ?½ºÌå¹û½ºîé°²ÉíÁÙ´²£¬Í¨¹ý´óÁ¿ÁÙ´²³ÉЧ¶Ô±È£¬È·¶¨°²È«ÐÔ¡¢ÓÐЧÐÔ¡£
1¡¢½ºÌå¹û½ºîéÒ©´ú¶¯Á¦Ñ§¼°°²È«ÐÔ×êÑÐ
Á˾֣ºîéÎüÊÕÁ¿( ÒÔ AUC0£tºÍCmax¼Æ) ½ºÌå¹û½ºî齺ÄÒ£¼½ºÌå¹û½ºîé¿ÅÁ££¼èÛéÚËáî鼨¿ÅÁ££¼èÛéÚËáîé¼ØÆ¬£¬Åú×¢ÊÜÊÔÔì¼ÁµÄÈËÌåîéÎüÊÕµÍÓڲαÈÔì¼Á¡£
½áÂÛ£º½¡È«ÊÜÊÔÕßµ¥´Î¿Ú·þ½ºÌå¹û½ºîé¿ÅÁ£¡¢½ºÌå¹û½ºî齺ÄÒµÄÈËÌåîéÎüÊÕµÍÓÚèÛéÚËáîé¼ØÆ¬ºÍèÛéÚËáî鼨¿ÅÁ££¬ÓµÓÐÓÅÁ¼µÄ°²È«ÐÔ¡£

2¡¢½ºÌå¹û½ºîéÈËÌåÎüÊÕ×êÑÐ
Á˾֣ºîéµÄÎüÊÕÁ¿ÓɶൽÉÙ˳´ÎΪ£º½ºÌå´ÎèÛéÚËáî鯬 > èÛéÚËáî鼨½ºÄÒ >½ºÌ¬¹û½ºî齺ÄÒ
ÎüÊÕ¿ì¶Å×ɿ쵽Âý˳´ÎΪ£º½ºÌå´ÎèÛéÚËáî鯬 > èÛéÚËáî鼨½ºÄÒ > ½ºÌ¬¹û½ºî齺ÄÒ
½áÂÛ£ºÏà±Å×ÚèÛéÚËáî鼨½ºÄҺͽºÌå´ÎèÛéÚËáî鯬£¬»¼ÕßÔÚ¿Ú·þ½ºÌ¬¹û½ºî齺ÄÒºóîéµÄÎüÊÕÔ½·¢»ºÂý£¬ÇÒÎüÊÕÁ¿¼«ÉÙ£¬°²È«¿¿µÃס¡£

3¡¢¹û½ºîéËÄÁªÁÆ·¨Ò½Öγà×ÓHpÓйØÎ¸Ñ×ÁÆÐ§×êÑÐ
Á˾֣ºÒ½ÖÎ×éÒ½ÖÎ×ÜÓÐЧÂÊ¡¢ÓÄÃÅÂݸ˾ú½â³ýÂʾù¸ßÓÚ¶ÔÕÕ×é( P £¼ 0. 05) ; Ò½ÖÎ×é²»Á¼·´Ó³²úÉúÂʵÍÓÚ¶ÔÕÕ×é( P £¼ 0. 05) ¡£
½áÂÛ£ºÔÚ³à×ÓÓÄÃÅÂݸ˾úÓйØÐÔθÑ×µÄÁÙ´²Ò½ÖÎÖУ¬ÀûÓú¬îé¼ÁËÄÁªÁÆ·¨Ò½ÖÎÁÆÐ§È·ÇÓ×¢ÎÞÑϳÁ²»Á¼·´Ó³¡£

Èý¡¢Å·²©ABGÔìÒ©°²ÐÀ?½ºÌå¹û½ºîé²úÆ·ÓÅÊÆ¡ª¡ªµÚÈý´úîéÔì¼Á£¬°²È«ÓÐЧ»¤Î¸¼Á
1¡¢´ÓÒ©ÎïÆô³Ì£ºÊÀ½ç³õ´´ÔÑÐÒ©Æ·£»Ò©Æ·³ß¶È¸ßÓÚ¹ú¶È³ß¶È¡£
2¡¢´Ó»¼Õ߯ô³Ì£º¼ÛÖµÊÊÖУ¬Ò×ÓÚ½ÓÊÜ£»¹æ¸ñ¶à¶à£¬ÁÙ´²Ñ¡Ôñ¶àÑù»¯¡£
3¡¢´ÓÉç»áÆô³Ì£ºÈÙ»ñ2012Äê¡°Äê¶È²ÔÉú°²ÐĽ±¡±µÈ¶àÏîÈÙÓþ£»È«¹ú³©Ïú30Ä꣬°²È«ÓÐЧ»ñÈϿɡ£

